4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

Base Information

Chemical Name:4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride
CAS No.:1609575-65-6
Molecular Formula:C₁₆H₁₇F₆NO₃*ClH
Molecular Weight:421.767
Hs Code.:

Synonyms:4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

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Chemical Property of 4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

Chemical Property:

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Technology Process of 4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

There total 5 articles about 4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1609575-64-5
4,4,4-trifluoro-3-[2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyronitrile

: 1609575-65-6
4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 110 ℃; for 4h;

Reference yield:

: 30914-89-7
2-(3-(trifluoromethyl)phenyl)morpholine

: 1609575-65-6
4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.83 h / 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 0.33 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

4.1: N,N-dimethyl-formamide / 2 h / 60 °C

5.1: hydrogenchloride / water / 4 h / 110 °C

With hydrogenchloride; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 3,3,3-trifluoro-2-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-propan-1-ol

: 1609575-65-6
4,4,4-trifluoro-3-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

2: N,N-dimethyl-formamide / 2 h / 60 °C

3: hydrogenchloride / water / 4 h / 110 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;