2-chloro-N-(2,4-dibromophenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2,4-dibromophenyl)acetamide
• CAS No.: 96686-52-1
• Molecular Formula: C₈H₆Br₂ClNO
• Molecular Weight: 327.403
• DSSTox Substance ID: DTXSID201280730
• Mol file: 96686-52-1.mol

Synonyms:2-chloro-N-(2,4-dibromophenyl)acetamide;96686-52-1;SCHEMBL10603799;DTXSID201280730;AKOS001043294;MS-1516;CS-0218669;EN300-01669;Z56869434

Chemical Property of 2-chloro-N-(2,4-dibromophenyl)acetamide

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 326.84842
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)Br)NC(=O)CCl

Technology Process of 2-chloro-N-(2,4-dibromophenyl)acetamide

There total 1 articles about 2-chloro-N-(2,4-dibromophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-dibromo-aniline (615-57-6) + chloroacetyl chloride (79-04-9) → 2-Chloro-N-(2,4-dibromo-phenyl)-acetamide (96686-52-1)

Guidance literature:

In toluene; for 3h; Heating;

DOI:10.1135/cccc19932211

Reference yield: 90.0%

3-(benzo[d][1,3]dioxol-5-ylmethyl)-2-mercaptoquinazolin-4(3H)-one + 2-Chloro-N-(2,4-dibromo-phenyl)-acetamide (96686-52-1) → 2-((3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(2,4-dibromophenyl)acetamide

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2021.128308

Reference yield: 83.0%

4-(6-iodo-2-mercapto-4-oxoquinazolin-3(4H)-yl)benzenesulfonamide + 2-Chloro-N-(2,4-dibromo-phenyl)-acetamide (96686-52-1) → N-(2,4-dibromophenyl)-2-(6-iodo-4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinazolin-2-ylthio)acetamide

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 8h;

DOI:10.1016/j.bioorg.2020.104618

upstream raw materials:

2,4-dibromo-aniline

chloroacetyl chloride

Downstream raw materials:

<2.4-Dibrom-anilinocarbonylmethyl>-triphenyl-phosphonium-chlorid