N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

Base Information

• Chemical Name: N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester
• CAS No.: 933675-84-4
• Molecular Formula: C₁₉H₂₀BrNO₃
• Molecular Weight: 390.277
• Mol file: 933675-84-4.mol

Synonyms:N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

Chemical Property of N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

There total 2 articles about N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(S-2-methanesulfonyloxymethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (238420-22-9) → N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (933675-84-4)

Guidance literature:

With lithium bromide; In acetone; for 24h; Heating / reflux;

Reference yield:

N-(S-2-hydroxymethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (238420-21-8) → N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (933675-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; hydrogenchloride; sodium bicarbonate / hexane; toluene

2: lithium bromide / water; ethyl acetate; acetone

With pyridine; hydrogenchloride; lithium bromide; sodium bicarbonate; In hexane; water; ethyl acetate; acetone; toluene;

Reference yield: 50.0%

N-(S-2-bromomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (933675-84-4) + potassium thioacetate (10387-40-3) → N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester (81110-73-8)

Guidance literature:

In isobutyl methyl ether; at 50 ℃; for 3.5h;

upstream raw materials:

N-(S-2-methanesulfonyloxymethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

N-(S-2-hydroxymethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester

Downstream raw materials:

N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester