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Racecadotril

Base Information Edit
  • Chemical Name:Racecadotril
  • CAS No.:81110-73-8
  • Deprecated CAS:81110-60-3
  • Molecular Formula:C21H23NO4S
  • Molecular Weight:385.484
  • Hs Code.:29309090
  • European Community (EC) Number:688-010-7
  • NSC Number:759828
  • UNII:76K53XP4TO
  • DSSTox Substance ID:DTXSID8045513
  • Nikkaji Number:J545.246E
  • Wikipedia:Racecadotril
  • Wikidata:Q416677
  • NCI Thesaurus Code:C66503
  • Pharos Ligand ID:CJN9Q8QC5Z8F
  • Metabolomics Workbench ID:152810
  • ChEMBL ID:CHEMBL2103772
  • Mol file:81110-73-8.mol
Racecadotril

Synonyms:Glycine,N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-, phenylmethyl ester, (?à)-;Acetorphan;Cadotril;Racecadotril;Redotil;Tiorfan;

Suppliers and Price of Racecadotril
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Racecadotril
  • 10g
  • $ 250.00
  • TCI Chemical
  • Racecadotril >99.0%(HPLC)(N)
  • 1g
  • $ 27.00
  • Sigma-Aldrich
  • Racecadotril ≥98% (HPLC)
  • 10mg
  • $ 81.50
  • Sigma-Aldrich
  • Racecadotril European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Racecadotril European Pharmacopoeia (EP) Reference Standard
  • y0000896
  • $ 190.00
  • Sigma-Aldrich
  • Racecadotril for peak identification European Pharmacopoeia (EP) Reference Standard
  • y0000902
  • $ 190.00
  • Sigma-Aldrich
  • Racecadotril ≥98% (HPLC)
  • 50mg
  • $ 315.00
  • DC Chemicals
  • Racecadotril >98%
  • 1 g
  • $ 300.00
  • CSNpharm
  • Racecadotril
  • 250mg
  • $ 51.00
  • Crysdot
  • Racecadotril 98+%
  • 100g
  • $ 277.00
Total 203 raw suppliers
Chemical Property of Racecadotril Edit
Chemical Property:
  • Appearance/Colour:White to off-white crystalline power 
  • Melting Point:89 °C 
  • Refractive Index:1.601 
  • Boiling Point:574.5 °C at 760 mmHg 
  • PKA:13.63±0.46(Predicted) 
  • Flash Point:301.2 °C 
  • PSA:97.77000 
  • Density:1.206 g/cm3 
  • LogP:3.37550 
  • Storage Temp.:Refrigerator 
  • Solubility.:DMSO: ≥44mg/mL 
  • XLogP3:3.3
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:11
  • Exact Mass:385.13477939
  • Heavy Atom Count:27
  • Complexity:485
Purity/Quality:

99% *data from raw suppliers

Racecadotril *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xn,N 
  • Hazard Codes:Xn,N 
  • Statements: 22-50/53 
  • Safety Statements: 60-61 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2
  • Recent ClinicalTrials:Anti-Secretory Drug in Treatment of Acute Watery Diarrhea
  • Recent EU Clinical Trials:COMbination therapy for PulmonAry hypertension using RacEcadotril (COMPARE).
  • Description Racecadotril (also called acetorphan) is a kind of antidiarrheal drug acting as a peripherally acting enkephalinase inhibitor. It has an antisecretory effect, reducing the secretion of water and electrolytes into the intestine. Racecadotril is a protodrug, being broken down into the active ingredient, thiorphan. Thiorphan exerts its inhibitory effect on enkephalinase, reducing the amount of secreted water produced by the intestines. In this case, the body loses less fluid, and the symptoms of diarrhea can be alleviated. Acetorphan is an orally-active enkephalinase inhibitor introduced in 1993 for the treatment of acute diarrhea in adults.It displays antidiarrheal activity via a purely antisecretory mechanism without inhibiting intestinal transit. Acetorphan acts as rapidly as loperamide, a classical mu opiate receptor agonist that exhibits its antidiarrheal effect via an antitransit mechanism, without producing constipation or other side effects. The novel mechanism of action may render acetorphan potentially useful in the management of infectious diarrhea. Racecadotril is an enkephalinase inhibitor that prevents the degradation of endogenous opioids. It demonstrates antidiarrheal activity by reducing hypersecretion of water and electrolytes into the intestinal lumen. Racecadotril is a pro-drug that is metabolized in vivo into the active compound, thiorphan .
  • Uses Antidiarrheal; enkephalinase inhibitor, reducing the amount of water and electrolytes into the intestine.
  • Clinical Use Treatment of acute diarrhoea
  • Drug interactions Potentially hazardous interactions with other drugs None known
Technology Process of Racecadotril

There total 39 articles about Racecadotril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
at 55 ℃; for 2h; Industrial scale;
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