(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester
CAS No.:154865-89-1
Molecular Formula:C₂₈H₃₉NO₇Si
Molecular Weight:529.706
Hs Code.:

(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

Synonyms:(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

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Chemical Property of (2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

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Technology Process of (2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

There total 8 articles about (2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 75-16-1
methylmagnesium bromide

: 154865-85-7
(2R,4aR,8S,8aR)-7-Oxo-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

: (2R,4aR,7R,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

: 154865-89-1
(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

Guidance literature:: DOI:10.1016/0040-4039(96)00021-4

Reference yield:

: 130539-12-7
N-Benzyloxycarbonyl-1,5-dideoxy-1,5-imino-D-glucitol

: 154865-89-1
(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / TosOH

2: 68 percent / Bu₂SnO, NEt₃ / 24 h / 25 °C

3: Hunig's base

4: 91 percent / Bu₄NOH / dioxane; H₂O / 25 °C

5: DMSO / trifluoroacetic acid / 3 h / -70 - -30 °C

6: 68 percent

With tetra(n-butyl)ammonium hydroxide; di(n-butyl)tin oxide; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; trifluoroacetic acid;
DOI:10.1016/0040-4039(96)00021-4

Reference yield:

: 19130-96-2
1,5-dideoxy-1,5-imino-D-glucitol

: 154865-89-1
(2R,4aR,7S,8S,8aR)-7-Hydroxy-7-methyl-2-phenyl-8-(2-trimethylsilanyl-ethoxymethoxy)-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / Na₂CO₃ / H₂O

2: 65 percent / TosOH

3: 68 percent / Bu₂SnO, NEt₃ / 24 h / 25 °C

4: Hunig's base

5: 91 percent / Bu₄NOH / dioxane; H₂O / 25 °C

6: DMSO / trifluoroacetic acid / 3 h / -70 - -30 °C

7: 68 percent

With tetra(n-butyl)ammonium hydroxide; di(n-butyl)tin oxide; sodium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; trifluoroacetic acid;
DOI:10.1016/0040-4039(96)00021-4