2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

Base Information

Chemical Name:2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine
CAS No.:133732-88-4
Molecular Formula:C₃₃H₃₅NO₅S
Molecular Weight:557.711
Hs Code.:

Synonyms:2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

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Chemical Property of 2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

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Technology Process of 2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

There total 10 articles about 2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 133732-87-3
2R,4S,5R,1'S-2-<1'-Benzyloxy-2'-hydroxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

: 133732-88-4
2R,4S,5R,1'S-2-<1',2'-Dibenzyloxyethyl>-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 3h;

Reference yield:

: 212912-47-5
2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

: 133732-88-4
(2R,4S,5R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*Et₂O / CH₂Cl₂ / 1 h / -78 °C

2: OsO₄, Me₃NO

3: 1.) NaIO₄, 2.) NaBH₄

4: H₂ / 10percent Pd-C

5: NaH

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; trimethylamine-N-oxide; boron trifluoride diethyl etherate; hydrogen; sodium hydride; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/jo00025a001

Reference yield:

: 136862-94-7
(R)-2-Benzyloxymethoxy-2-[(2R,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-ethanol

: 133732-88-4
(2R,4S,5R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd-C

2: NaH

With hydrogen; sodium hydride; palladium on activated charcoal;
DOI:10.1021/jo00025a001