5-hydroxy-4-phenylthiopentanonitrile

Base Information

• Chemical Name: 5-hydroxy-4-phenylthiopentanonitrile
• CAS No.: 108078-52-0
• Molecular Formula: C₁₁H₁₃NOS
• Molecular Weight: 207.296
• Mol file: 108078-52-0.mol

Synonyms:5-hydroxy-4-phenylthiopentanonitrile

Chemical Property of 5-hydroxy-4-phenylthiopentanonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-4-phenylthiopentanonitrile

There total 1 articles about 5-hydroxy-4-phenylthiopentanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-Pentenenitrile (592-51-8) + diphenyldisulfane (882-33-7) → 5-hydroxy-4-phenylthiopentanonitrile (108078-52-0) + 4-hydroxy-5-phenylthiopentanonitrile (108078-51-9)

Guidance literature:

With manganese triacetate; trifluoroacetic acid; Yield given. Multistep reaction; 1) in dichloromethane, 2) hydrolysis under basic conditions;

DOI:10.1016/S0040-4039(00)85194-1

Reference yield: 90.0%

5-hydroxy-4-phenylthiopentanonitrile (108078-52-0) → 5-[(phenylsulfanyl)methyl]dihydrofuran-2(3H)-2-one (108078-64-4)

Guidance literature:

With cobalt(II) chloride; In water; at 170 ℃; for 5h;

Reference yield:

5-hydroxy-4-phenylthiopentanonitrile (108078-52-0) → 4-hydroxy-5-phenylthio-N-benzylpentanamide (117768-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / cobalt(II) chloride hexahydrate / H₂O / 5 h / 170 °C

2: 77 percent / tetrahydrofuran / 72 h / Heating

With cobalt(II) chloride; In tetrahydrofuran; water;

upstream raw materials:

4-Pentenenitrile

diphenyldisulfane

Downstream raw materials:

5-[(phenylsulfanyl)methyl]dihydrofuran-2(3H)-2-one

4-hydroxy-5-phenylthio-N-benzylpentanamide