methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate
CAS No.:1195782-66-1
Molecular Formula:C₁₄H₁₂FNO₃
Molecular Weight:261.253
Hs Code.:

Synonyms:methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Chemical Property of methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Technology Process of methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

There total 1 articles about methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 25991-27-9
methyl 2-oxo-2H-pyrane-3-carboxylate

: 452-71-1
4-fluor-2-methylaniline

: 1195782-66-1
methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: methyl 2-oxo-2H-pyrane-3-carboxylate; 4-fluor-2-methylaniline; In N,N-dimethyl-formamide; at 0 ℃; for 7h; Inert atmosphere;

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.10.037

Reference yield: 85.0%

: 1195782-66-1
methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1195782-67-2
1-(4-fluoro2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Guidance literature:: methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 1195782-66-1
methyl-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1195780-06-3
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;