25991-27-9 Usage
Chemical Properties
LIGHT YELLOW CRYSTALLINE SOLID
Uses
Methyl 2-oxo-2H-pyran-3-carboxylate is used as a reagent to investigate alfa, beta-unsaturated carbonyl compounds for their cytotoxic profiles against oral human normal and tumor cells.
General Description
Methyl 2-oxo-2H-pyran-3-carboxylate is a cyclic α,β -unsaturated ketone. It activates caspases-3, -8 and -9 weakly in HL-60 cells.
Check Digit Verification of cas no
The CAS Registry Mumber 25991-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,9,9 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 25991-27:
(7*2)+(6*5)+(5*9)+(4*9)+(3*1)+(2*2)+(1*7)=139
139 % 10 = 9
So 25991-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O4/c1-10-6(8)5-3-2-4-11-7(5)9/h2-4H,1H3
25991-27-9Relevant articles and documents
Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones
Liang, Xiao-Wei,Zhao, Yunlong,Si, Xu-Ge,Xu, Meng-Meng,Tan, Jia-Hao,Zhang, Zhi-Mao,Zheng, Cheng-Gong,Zheng, Chao,Cai, Quan
supporting information, p. 14562 - 14567 (2019/09/06)
An enantioselective chemical synthesis of arene cis-dihydrodiols has been realized from 2-pyrones through sequential ytterbium-catalyzed asymmetric inverse-electron-demand Diels–Alder (IEDDA) reaction of 2-pyrones and retro-Diels–Alder extrusion of CO2. By using this strategy, a series of substituted arene cis-dihydrodiols can be obtained efficiently with high enantioselectivity (>99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)-MK7607 and 1-epi-(+)-MK7607 were accomplished.