2-Amino-N-phenylacetamide

Base Information

• Chemical Name: 2-Amino-N-phenylacetamide
• CAS No.: 555-48-6
• Deprecated CAS: 403652-19-7
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• European Community (EC) Number: 209-100-0
• NSC Number: 226561
• UNII: 6TY4B5Z38R
• DSSTox Substance ID: DTXSID70185878
• Nikkaji Number: J37.708B
• Wikipedia: 2-Aminoacetanilide
• Wikidata: Q27896876
• ChEMBL ID: CHEMBL1412864
• Mol file: 555-48-6.mol

Synonyms:2-Amino-N-phenylacetamide;555-48-6;2-AMINOACETANILIDE;Glycine anilide;N-Glycylaniline;Aminoacetic anilide;Glycinanilide;Benzokoll;Glycocollanilide;Amino-acetanilid;Acetanilide, ar'-amino-;Acetamide, 2-amino-N-phenyl-;USAF EK-13;Acetanilide,2-amino-;Acetanilide, 2-amino-;6TY4B5Z38R;EINECS 209-100-0;MFCD06662103;NSC 226561;NSC-226561;n-phenylglycinamide;32074-28-5;2-amino-N-phenyl-acetamide;NSC14288;Aminoacetanilid;alpha-Aminoacetanilide;NCIStruc1_000005;NCIStruc2_000092;UNII-6TY4B5Z38R;2-azanyl-N-phenyl-ethanamide;SCHEMBL188327;CHEMBL1412864;DTXSID70185878;NCI14288;CCG-37596;NCGC00013186;NSC226561;STL183954;AKOS000183394;AB22065;NCGC00013186-02;NCGC00096307-01;BS-28810;NCI60_000936;BB 0254727;CS-0117648;EN300-58358;A833219;Q27896876;F3308-3806

Chemical Property of 2-Amino-N-phenylacetamide

Chemical Property:

• Boiling Point: 361.5°Cat760mmHg
• Flash Point: 172.4°C
• PSA: 55.12000
• Density: 1.203g/cm³
• LogP: 1.35710
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)CN

Technology Process of 2-Amino-N-phenylacetamide

There total 27 articles about 2-Amino-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

α-azidoacetanilide (10258-71-6) → 2-amino-N-phenyl-acetamide (555-48-6)

Guidance literature:

With 3.5% Pd/C; hydrogen; In methanol; Autoclave;

DOI:10.1016/j.tet.2011.05.001

Reference yield: 98.0%

benzyl (2-oxo-2-(phenylamino)ethyl)carbamate (6833-09-6) → 2-amino-N-phenyl-acetamide (555-48-6)

Guidance literature:

With palladium on activated charcoal; In ethanol;

DOI:10.1080/10426507.2018.1542397

Reference yield: 75.61%

BOC-glycine (4530-20-5) + aniline (62-53-3) → 2-amino-N-phenyl-acetamide (555-48-6)

Guidance literature:

BOC-glycine; aniline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

hydroxyimino-N-phenylacetamide

2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-N-phenylacetamide

N-chloroacetyl-aniline

glycine ethyl ester hydrochloride

Downstream raw materials:

nitrilotri-acetic acid diamid-anilide

N-ethoxycarbonyl-glycine anilide

methyl 2-[2-(phenylaminocarbonylmethyl-sulfamoyl)-4,5-dimethoxyphenyl]acetate

C₃₂H₃₁N₅O₄

Refernces

• 1、 Deng, Xuemei,Feng, Hanzhong,Feng, Yiyue,He, Yongxing,Jiang, Weifan,Li, Junfang,Li, Zhao,Liu, Dan,Lu, Yingmei,Shi, Tao,Wang, Zhen,Zhang, Honghua,Zhang, Jian. "Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo". . . Retrieved 2021/10/12.
• 2、 Ali, Rafat.,Aronimo, Babatunde. S.,Ezugwu, James. A.,Ibeji, Collins. U.,Okoro, Uchechukwu. C.,Ugwu, David. I.. "Synthesis, molecular docking and antimalarial activity of phenylalanine-glycine dipeptide bearing sulphonamide moiety". . . Retrieved 2021/08/10.