R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

Base Information

Chemical Name:R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester
CAS No.:637008-57-2
Molecular Formula:C₂₁H₂₀N₂O₇
Molecular Weight:412.399
Hs Code.:

Synonyms:R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

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Chemical Property of R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

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Technology Process of R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

There total 5 articles about R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 524-38-9
N-hydroxyphthalimide

: 637008-56-1
(R)-2-Benzyloxycarbonylamino-4-methanesulfonyloxy-butyric acid methyl ester

: 637008-57-2
R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1139/v03-122

Reference yield:

: 1152-62-1,4434-61-1,28862-80-8
(2R)-2-[[(benzyloxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid

: 637008-57-2
R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen fluoride; methyl iodide / acetic acid / 15 h

2.1: potassium hydroxide / methanol / 18 h / 20 °C

2.2: 27 / 66 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 20 °C

With potassium hydroxide; hydrogen fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl iodide; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1139/v03-122

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 637008-57-2
R-2-benzyloxycarbonylamino-4-phthalimidooxybutyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / 22 h / 20 °C

2.1: hydrogen fluoride; methyl iodide / acetic acid / 15 h

3.1: potassium hydroxide / methanol / 18 h / 20 °C

3.2: 27 / 66 h / 20 °C

4.1: triethylamine / dichloromethane / 2 h / 0 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 20 °C

With potassium hydroxide; hydrogen fluoride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl iodide; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1139/v03-122