(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Base Information

Chemical Name:(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid
CAS No.:443149-98-2
Molecular Formula:C₂₆H₃₄N₂O₅
Molecular Weight:454.566
Hs Code.:

Synonyms:(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Suppliers and Price of (3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

There total 6 articles about (3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 443149-77-7
(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid tert-butyl ester

: 443149-98-2
(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo0110698

Reference yield:

: 35373-92-3
L-phenylalanine methylamide

: 443149-98-2
(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / tetrabutylammonium iodide; potassium carbonate / dimethylformamide / 144 h / 60 °C

2: 92 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 0.5 h / 20 °C / pH 10

3: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 144287-83-2
(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5-methylhexanoate

: 443149-98-2
(3R)-3-{[benzyloxycarbonyl-(1S)-(1-methylcarbamoyl-2-phenylethyl)amino]methyl}-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / lithium borohydride; MeOH / diethyl ether / 1.5 h / 0 °C

2: 89 percent / PPh₃; CBr₄ / CH₂Cl₂ / 2 h / 20 °C

3: 42 percent / tetrabutylammonium iodide; potassium carbonate / dimethylformamide / 144 h / 60 °C

4: 92 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 0.5 h / 20 °C / pH 10

5: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

With methanol; lithium borohydride; carbon tetrabromide; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698