5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole
CAS No.:1427278-65-6
Molecular Formula:C₃₈H₅₂N₄O₇SSi
Molecular Weight:737.005
Hs Code.:

Synonyms:5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

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Chemical Property of 5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

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Technology Process of 5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

There total 4 articles about 5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₅₂N₄O₅SSi

: 1427278-65-6
5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With ammonium molybdate tetrahydrate; dihydrogen peroxide; In ethanol; at 0 - 20 ℃; for 6h;
DOI:10.1016/j.tet.2013.02.033

Reference yield:

: 1431985-93-1
C₃₁H₄₆O₆Si

: 1427278-65-6
5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / -20 - 0 °C / Inert atmosphere

3: dihydrogen peroxide; ammonium molybdate tetrahydrate / ethanol / 6 h / 0 - 20 °C

With sodium tetrahydroborate; ammonium molybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; 2: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.02.033

Reference yield:

: 1388144-87-3
((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

: 1427278-65-6
5-((S)-3-(methoxymethoxy)-3-((4R,5R)-5-((R)-4-tert-butyldiphenylsilyloxypentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: osmium(VIII) oxide; sodium periodate; 4-methylmorpholine N-oxide / tetrahydrofuran; water; toluene / 3 h / 20 °C

2: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / -20 - 0 °C / Inert atmosphere

4: dihydrogen peroxide; ammonium molybdate tetrahydrate / ethanol / 6 h / 0 - 20 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; ammonium molybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; 4-methylmorpholine N-oxide; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; water; toluene; 3: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.02.033