(E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one

Base Information

• Chemical Name: (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one
• CAS No.: 1636155-21-9
• Molecular Formula: C₁₄H₁₅BrO₂S₂
• Molecular Weight: 359.308
• Mol file: 1636155-21-9.mol

Synonyms:(E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one

Chemical Property of (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one

There total 1 articles about (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,4-bis(methylthio)but-3-en-2-one (17649-86-4) + 5-bromo-2-methoxybenzaldehyde (25016-01-7) → (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one (1636155-21-9)

Guidance literature:

With sodium hydroxide; In ethanol; at 10 - 20 ℃; for 0.666667h;

DOI:10.1039/c4ra02891k

Reference yield: 84.0%

(E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one (1636155-21-9) + 1,2-diamino-benzene (95-54-5) → (E)-2-(5-bromo-2-methoxystyryl)-1H-benzo[d]imidazole

Guidance literature:

With copper(l) iodide; acetic acid; In water; at 100 ℃;

DOI:10.1016/j.tet.2015.06.008

Reference yield: 72.0%

ethanol (64-17-5) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one (1636155-21-9) + guanidine nitrate (506-93-4) → 4-ethoxy-6-(4-(5-bromo-2-methoxyphenyl)-1H-pyrrol-3-yl)pyrimidin-2-amine (1636155-38-8)

Guidance literature:

[(p-methylphenyl)sulfonylmethyl]isonitrile; (E)-5-(5-bromo-2-methoxyphenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one; guanidine nitrate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.0833333h;

ethanol; In tetrahydrofuran; mineral oil; at 70 ℃; for 10h; regioselective reaction;

DOI:10.1039/c4ra02891k

upstream raw materials:

4,4-bis(methylthio)but-3-en-2-one

5-bromo-2-methoxybenzaldehyde

Downstream raw materials:

4-methoxy-6-(4-(5-bromo-2-methoxyphenyl)-1H-pyrrol-3-yl)pyrimidin-2-amine

4-ethoxy-6-(4-(5-bromo-2-methoxyphenyl)-1H-pyrrol-3-yl)pyrimidin-2-amine