1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Base Information

• Chemical Name: 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline
• CAS No.: 1255086-62-4
• Molecular Formula: C₂₄H₂₇ClN₄O₃
• Molecular Weight: 454.956

Synonyms:1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Chemical Property of 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Chemical Property:

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Technology Process of 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

There total 2 articles about 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline (1255086-61-3) → 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline (1255086-62-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.ejmech.2010.08.064

Reference yield:

1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline (1255086-60-2) → 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline (1255086-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: hydrazine hydrate / ethanol / 2 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/ardp.200900296

Reference yield: 78.0%

1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline (1255086-62-4) + 4-Methoxyphenyl isothiocyanate (2284-20-0) → C32H34ClN5O4S (1255086-63-5)

Guidance literature:

With acetic acid; In ethanol; for 2h; Reflux;

DOI:10.1002/ardp.200900296

upstream raw materials:

1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Downstream raw materials:

C₃₁H₃₀BrClN₄O₃

C₃₂H₃₃ClN₄O₃

C₃₁H₃₀Cl₂N₄O₃

C₃₁H₃₀Cl₂N₄O₃

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