1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Base Information

Chemical Name:1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline
CAS No.:1255086-61-3
Molecular Formula:C₂₆H₂₉ClN₂O₄
Molecular Weight:468.98
Hs Code.:

Synonyms:1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

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Chemical Property of 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

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Technology Process of 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

There total 1 articles about 1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 1255086-60-2
1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

: 105-36-2
ethyl bromoacetate

: 1255086-61-3
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2010.08.064

Reference yield: 72.0%

: 1255086-61-3
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

: 1255086-62-4
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2010.08.064

Reference yield:

: 1255086-61-3
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

: 1255086-63-5
C₃₂H₃₄ClN₅O₄S

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: acetic acid / ethanol / 2 h / Reflux

With hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1002/ardp.200900296