1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Base Information

Chemical Name:1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline
CAS No.:1255086-60-2
Molecular Formula:C₂₂H₂₃ClN₂O₂
Molecular Weight:382.89
Hs Code.:

Synonyms:1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

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Chemical Property of 1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Chemical Property:

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Technology Process of 1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

There total 1 articles about 1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 24706-47-6
3-(4-chlorophenylamino)-5,5-dimethylcyclohex-2-enone

: 123-30-8
4-amino-phenol

: 1255086-60-2
1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Guidance literature:: With acetic acid; In ethanol;
DOI:10.1016/j.ejmech.2010.08.064

Reference yield: 81.3%

: 1255086-60-2
1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

: 105-36-2
ethyl bromoacetate

: 1255086-61-3
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(ethoxycarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2010.08.064

Reference yield:

: 1255086-60-2
1-(4-chlorophenyl)-7,7-dimethyl-3-(4-hydroxyphenyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

: 1255086-62-4
1-(4-chlorophenyl)-7,7-dimethyl-3-[4-(hydrazinocarbonylmethoxy)phenyl]-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: hydrazine hydrate / ethanol / 2 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ardp.200900296