3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1552301-08-2
Molecular Formula:C₁₈H₂₂BFN₂O₅S
Molecular Weight:408.258
Hs Code.:

Synonyms:3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of 3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of 3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

There total 7 articles about 3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: N-(5-bromo-2-methoxypyridin-3-yl)-3-fluorobenzenesulfonamide

: 73183-34-3
bis(pinacol)diborane

: 1552301-08-2
3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.05.025

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1552301-08-2
3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 12 h / 0 - 50 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 50 °C / Inert atmosphere

3: pyridine / 24 h / 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin(II) chloride dihdyrate; potassium acetate; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1016/j.ejmech.2015.05.025

Reference yield:

: 152684-30-5
5-bromo-2-methoxy-3-nitropyridine

: 1552301-08-2
3-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 50 °C / Inert atmosphere

2: pyridine / 24 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin(II) chloride dihdyrate; potassium acetate; In 1,4-dioxane; ethyl acetate;
DOI:10.1016/j.ejmech.2015.05.025