tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate
• CAS No.: 1432677-22-9
• Molecular Formula: C₁₆H₂₃ClN₂O₃
• Molecular Weight: 326.823
• Mol file: 1432677-22-9.mol

Synonyms:tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(4-chloro-phenyl)-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (849106-90-7) → tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate (1432677-22-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 20.16h;

Reference yield:

tert-butyl methyl piperazine-1,3-dicarboxylate (129799-08-2) → tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate (1432677-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; copper diacetate / 16 h / Molecular sieve

2: lithium borohydride / tetrahydrofuran; methanol / 20.16 h / 0 - 20 °C

With pyridine; lithium borohydride; copper diacetate; In tetrahydrofuran; methanol;

Reference yield:

4-Chlorophenylboronic acid (1679-18-1) → tert-butyl 4-(4-chlorophenyl)-3-(hydroxymethyl)piperazine-1-carboxylate (1432677-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; copper diacetate / 16 h / Molecular sieve

2: lithium borohydride / tetrahydrofuran; methanol / 20.16 h / 0 - 20 °C

With pyridine; lithium borohydride; copper diacetate; In tetrahydrofuran; methanol;

upstream raw materials:

4-Chlorophenylboronic acid

tert-butyl methyl piperazine-1,3-dicarboxylate

4-(4-chloro-phenyl)-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Downstream raw materials:

tert-butyl 4-(4-chlorophenyl)-3-((4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)methyl)piperazine-1-carboxylate