(R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Base Information

Chemical Name:(R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline
CAS No.:420133-91-1
Molecular Formula:C₁₅H₂₈N₂OS₂
Molecular Weight:316.532
Hs Code.:

Synonyms:(R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Suppliers and Price of (R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

There total 2 articles about (R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 420133-87-5
(R)-methyl-2-methyl-2-(4,5-dihydro-4-isopropyl-2-thiazolyl)propanedithioate

: 420133-91-1
(R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Guidance literature:: With triethylamine; at 20 ℃; for 48h;
DOI:10.1016/S0957-4166(01)00481-5

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 420133-91-1
(R,R)-4-isopropyl-2-{1-[N-(1-(hydroxymethyl)-2-methylpropyl)thiocarbamoyl]-1-methylethyl}-2-thiazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / Et₃N / 12 h / 20 °C

2.1: 98 percent / mesylchloride; Et₃N / tetrahydrofuran / 0.17 h / 20 °C

3.1: t-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C

3.2: tetrahydrofuran / 2 h / -40 °C

3.3: 83 percent / tetrahydrofuran / 20 °C

4.1: 98 percent / Et₃N / 48 h / 20 °C

With tert.-butyl lithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; cyclohexane;
DOI:10.1016/S0957-4166(01)00481-5