2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
• CAS No.: 174311-51-4
• Molecular Formula: C₁₈H₂₁N₃
• Molecular Weight: 279.385
• Mol file: 174311-51-4.mol

Synonyms:2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property of 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 12 articles about 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-49-0) → 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-51-4)

Guidance literature:

With hydrazine hydrate; In methanol; for 4h; Ambient temperature;

DOI:10.1021/jm950423p

Reference yield:

2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-64-9) → 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂

2: NaI / dimethylformamide

3: hydrazine / methanol / 4 h / 20 °C

With thionyl chloride; sodium iodide; hydrazine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0307640

Reference yield:

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-47-8) → 2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / dimethylformamide

2: hydrazine / methanol / 4 h / 20 °C

With sodium iodide; hydrazine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0307640

upstream raw materials:

2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Downstream raw materials:

VA 101