2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
• CAS No.: 174311-64-9
• Molecular Formula: C₁₈H₂₀N₂O
• Molecular Weight: 280.37
• Mol file: 174311-64-9.mol

Synonyms:2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property of 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 9 articles about 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester (174311-63-8) → 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-64-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.25h;

DOI:10.1021/jm950423p

Reference yield:

(2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin)-2-acetic acid methyl ester (608136-52-3) → 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-64-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h;

DOI:10.1021/jm0307640

Reference yield:

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) → 2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-64-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: NaH / 1,2-dimethoxy-ethane / 1 h / 0 °C

1.2: diethylchlorophosphate / 1,2-dimethoxy-ethane / 0.5 h

1.3: 70 percent / 1,2-dimethoxy-ethane / 14 h / 20 °C

2.1: 67 percent / aq. NaOH / methanol / 13 h / 20 - 60 °C

3.1: 64 percent / aq. NaOH; Bu₄NBr / benzene / 3 h / Heating

4.1: 84 percent / TFA; triethylsilane / 0.5 h / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 0.25 h

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; benzene;

DOI:10.1021/jm0307640

upstream raw materials:

2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

(2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin)-2-acetic acid methyl ester

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

(Z)-2,3-dihydro-2-[(methoxycarbonyl)methylen]-5-phenyl-1H-1,4-benzodiazepine

Downstream raw materials:

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

VA 101