2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

Chemical Name:2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
CAS No.:174311-49-0
Molecular Formula:C₂₆H₂₃N₃O₂
Molecular Weight:409.488
Hs Code.:

Synonyms:2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Chemical Property of 2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Technology Process of 2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 11 articles about 2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1074-82-4
potassium phtalimide

: 174311-47-8
2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-49-0
2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 14h;
DOI:10.1021/jm950423p

Reference yield:

: 174311-64-9
2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-49-0
2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: NaI / dimethylformamide

With thionyl chloride; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0307640

Reference yield:

: 2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

: 174311-49-0
2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / 1,2-dimethoxy-ethane / 1 h / 0 °C

1.2: diethylchlorophosphate / 1,2-dimethoxy-ethane / 0.5 h

1.3: 70 percent / 1,2-dimethoxy-ethane / 14 h / 20 °C

2.1: 67 percent / aq. NaOH / methanol / 13 h / 20 - 60 °C

3.1: 64 percent / aq. NaOH; Bu₄NBr / benzene / 3 h / Heating

4.1: 84 percent / TFA; triethylsilane / 0.5 h / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 0.25 h

6.1: SOCl₂ / CH₂Cl₂

7.1: NaI / dimethylformamide

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; tetrabutylammomium bromide; sodium hydride; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm0307640