(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

Base Information

Chemical Name:(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide
CAS No.:1374968-90-7
Molecular Formula:C₁₇H₂₂FN₅O₂S
Molecular Weight:379.458
Hs Code.:

Synonyms:(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

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Chemical Property of (R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

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Technology Process of (R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

There total 4 articles about (R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₀FN₅OS

: 1374968-90-7
(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; at 20 ℃; for 0.5h;

Reference yield:

: 1374968-91-8
(R)-2-(4-cyano-2,3-difluorophenylamino)-4-methylpentanamide

: 1374968-90-7
(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 130 °C

2: sodium hydroxide; dihydrogen peroxide / ethanol; water; dimethyl sulfoxide / 0.5 h / 20 °C

With dihydrogen peroxide; sodium hydride; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; mineral oil;

Reference yield:

: 143879-80-5
2,3,4-trifluorobenzonitrile

: 1374968-90-7
(R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 68 h / 20 °C

2: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 130 °C

3: sodium hydroxide; dihydrogen peroxide / ethanol; water; dimethyl sulfoxide / 0.5 h / 20 °C

With dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; mineral oil;