1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

Base Information

Chemical Name:1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one
CAS No.:127555-18-4
Molecular Formula:C₁₅H₁₃ClN₂O
Molecular Weight:272.734
Hs Code.:

Synonyms:1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

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Chemical Property of 1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

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Technology Process of 1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

There total 11 articles about 1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127555-70-8
1-(4-Chlorophenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]-pyridin-2-one

: 74-88-4
methyl iodide

: 127555-18-4
1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) THF, RT, 30 min, 2.) RT, 16 h;
DOI:10.1021/jm00172a004

Reference yield:

: 127555-94-6
2-[(4-Chlorophenyl)amino]-a,a-dimethyl-3-pyridineacetic acid

: 127555-18-4
1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 127555-18-4
1-(4-chlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo<2,3-b>pyridin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine, p-TsOH / H₂O / Heating

2: 97 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

3: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

4: NaOH / ethanol; H₂O / 16 h / Ambient temperature

6: 1.) NaH / 1.) hexane, THF, RT, 30 min, 2.) RT, 16 h

7: 100 percent / zinc dust, trimethylsilyl chloride (TMSCl) / tetrahydrofuran; H₂O / 5 h / Ambient temperature

8: 1.) NaH / 1.) THF, RT, 30 min, 2.) RT, 16 h

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; chloro-trimethyl-silane; thionyl chloride; sodium hydride; toluene-4-sulfonic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00172a004