Haloxydine

Base Information

• Chemical Name: Haloxydine
• CAS No.: 2693-61-0
• Molecular Formula: C₅HCl₂F₂NO
• Molecular Weight: 199.972
• Hs Code.: 2933399090
• UNII: EY89F0C6PF
• DSSTox Substance ID: DTXSID2042018
• Nikkaji Number: J7.650C
• Wikidata: Q27155811
• Mol file: 2693-61-0.mol

Synonyms:Haloxydine;2693-61-0;3,5-Dichloro-2,6-difluoro-4-pyridinol;3,5-dichloro-2,6-difluoropyridin-4-ol;Caswell No. 304A;Haloxydine [ISO:BSI];3,5-dichloro-2,6-difluoro-1H-pyridin-4-one;UNII-EY89F0C6PF;EY89F0C6PF;4-Pyridinol, 3,5-dichloro-2,6-difluoro-;3,5-Dichloro-2,6-difluoro-4-hydroxypyridine;EPA Pesticide Chemical Code 304200;C5HCl2F2NO;HALOXYDINE [ISO];SCHEMBL134038;C5-H-Cl2-F2-N-O;DTXSID2042018;CHEBI:82213;MFCD00236690;PP-493;AKOS006273925;4-Hydroxy-3,5-dichlorodifluoropyridine;FT-0693385;C19091;EN300-129947;3,5-Dichloro-2,6-difluoro-4-pyridinol, AldrichCPR;2,6-DIFLUORO-3,5-DICHLORO-4-HYDROXYPYRIDINE;Q27155811

Chemical Property of Haloxydine

Chemical Property:

• Vapor Pressure: 1.29mmHg at 25°C
• Melting Point: 101.5-102.5 °C
• Boiling Point: 173°C at 760 mmHg
• PKA: 3.28±0.33(Predicted)
• Flash Point: 58.4°C
• PSA: 33.12000
• Density: 1.7g/cm³
• LogP: 2.37220
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 198.9403254
• Heavy Atom Count: 11
• Complexity: 258

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

3,5-Dichloro-2,6-difluoro-4-pyridinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(NC(=C(C1=O)Cl)F)F)Cl

Technology Process of Haloxydine

There total 9 articles about Haloxydine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,5-dichloro-4-methoxy-2,6-difluoropyridine (2693-59-6) → haloxydine (2693-61-0)

Guidance literature:

With hydrogen iodide; In water; reflux, 3 h;;

Reference yield: 60.0%

3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → haloxydine (2693-61-0) + 2-Fluor-3,5-dichlor-4,6-dihydroxypyridin (17717-14-5)

Guidance literature:

With potassium hydroxide; In water; 85 °C, 20 h;;

Reference yield: 57.5%

3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → haloxydine (2693-61-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In not given; NaOH, reflux, 6.5 h;; precipitation at pH 1;;

upstream raw materials:

toluene-4-sulfonic acid

3,5-Dichloro-2,6-difluoro-pyridin-4-olateN-benzyl-N,N-dimethyl-hydrazinium;

3,5-dichloro-2,4,6-trifluoropyridine

3,5-dichloro-4-methoxy-2,6-difluoropyridine