2693-59-6

Basic information

• Product Name: Pyridine, 3,5-dichloro-2,6-difluoro-4-methoxy-
• Synonyms: Pyridine, 3,5-dichloro-2,6-difluoro-4-methoxy-;3,5-Dichloro-2,6-difluoro-4-Methoxypyridine, 97%
• CAS NO: 2693-59-6
• Molecular Formula: C₆H₃Cl₂F₂NO
• Molecular Weight: 214
• Mol File: 2693-59-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 3,5-dichloro-2,6-difluoro-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3,5-dichloro-2,6-difluoro-4-methoxy-(2693-59-6)
• EPA Substance Registry System: Pyridine, 3,5-dichloro-2,6-difluoro-4-methoxy-(2693-59-6)

Safety Data

• Hazardous Substances Data: 2693-59-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 1184172-35-7 2,6-difluoro-4-methoxypyridine 
• 2693-61-0 haloxydine 

Relevant articles and documents

Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake

A range of fluorinated 3-hydroxypyridin-4-ones has been synthesized where fluorine or fluorinated substituent was attached at 2- or 5- position of the pyridine ring in order to improve chemical and biological properties of 3-hydroxypyridin-4-ones. The synthetic route is different from conventional counterparts where a functional group is introduced to a preformed 3-hydroxypyridin-4-one ring. Herein, we introduce a novel method which starts with a fluorine containing precursor and the two hydroxyl groups at 3- and 4- positions of the pyridine ring are introduced at a later stage. The pK a values of the free ligands and the affinity constants of their iron complexes demonstrate that the presence of fluorine dramatically alters the values. The distribution coefficient values of the free ligands and corresponding iron(III) complexes between 1-octanol and MOPS buffer (pH 7.4) are also influenced. Glucuronidation and oxidation studies of selected fluorinated 3-hydroxypyridin-4-ones demonstrate that some such fluorinated compounds have clear advantage over deferiprone in that they are metabolized more slowly. Blood-brain barrier permeability studies indicated that although lipophilicity influences the permeability it is not the only factor. Two of the selected seven fluorinated 3-hydroxypyridin-4-ones have improved brain distribution when compared with deferiprone.

Polyhalogenated heterocyclic compounds: Part 52. [1] Macrocycles from 3,5-dichloro-2,4,6-trifluoropyridine

Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3,5-dichloro-2,4,6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hy