3,5-Dichloro-2,4,6-trifluoropyridine

Base Information

• Chemical Name: 3,5-Dichloro-2,4,6-trifluoropyridine
• CAS No.: 1737-93-5
• Molecular Formula: C5Cl2F3N
• Molecular Weight: 201.963
• Hs Code.: 2933399090
• European Community (EC) Number: 217-088-3
• UN Number: 9264
• UNII: 939242TZ0L
• DSSTox Substance ID: DTXSID2042357
• Nikkaji Number: J127.321C
• Wikidata: Q27271577
• Mol file: 1737-93-5.mol

Synonyms:3,5-dichloro-2,4-6-trifluoropyridine;DCTFPY

Chemical Property of 3,5-Dichloro-2,4,6-trifluoropyridine

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 23-24 °C
• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 159.5 °C at 760 mmHg
• PKA: -4.30±0.10(Predicted)
• Flash Point: 70.5 °C
• PSA: 12.89000
• Density: 1.694 g/cm³
• LogP: 2.80570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 200.9359889
• Heavy Atom Count: 11
• Complexity: 134
• Transport DOT Label: Poison Inhalation Hazard

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichlorotrifluoropyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T,T+
• Statements: 36/37/38-26
• Safety Statements: 26-37/39-36-45-36/37-28

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Other Toxic Gases & Vapors
• Canonical SMILES: C1(=C(C(=NC(=C1Cl)F)F)Cl)F

Technology Process of 3,5-Dichloro-2,4,6-trifluoropyridine

There total 16 articles about 3,5-Dichloro-2,4,6-trifluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.42%

2,3,4,5,6-pentachloropyridine (2176-62-7) → 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

With potassium fluoride; at 90 ℃; for 1.5h; Temperature; Reagent/catalyst; Concentration;

Reference yield: 93.0%

→ 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

Reference yield: 84.0%

potassium fluoride (7789-23-3) + 2,3,4,5,6-pentachloropyridine (2176-62-7) → 3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

In neat (no solvent); 400 °C (18 h);;

upstream raw materials:

piperidine

2,3,4,5,6-pentachloropyridine

Pentafluoropyridine

tetrachloro-monofluoropyridine

Downstream raw materials:

1-(3,5-dichloro-4,6-difluoro-2-pyridyl)-2-morpholinocyclohexene

3,5-dichloro-2,6-difluoro-4-(thiophenoxy)pyridine

2,4,6-(C₆H₅S)3-3,5-Cl₂-C₅N

4,6-(C₆H₅S)2-3,5-Cl₂-C₅FN

Refernces

• 1、 -. "Preparation method of 4-aminopyridine compound". Paragraph 0021-0023. . Retrieved 2021/02/06.
• 2、 -. "Novel method for continuous production of fluroxypyr intermediate 3,5-dichloro-2,4,6-trifluoropyridine". Paragraph 0040-0043; 0052. . Retrieved 2018/05/30.