(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

Base Information

Chemical Name:(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone
CAS No.:1196691-73-2
Molecular Formula:C₂₇H₃₄F₇N₃O₂Si
Molecular Weight:593.66
Hs Code.:

Synonyms:(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

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Chemical Property of (4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

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Technology Process of (4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

There total 1 articles about (4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196691-57-2
(4-amino-3-fluorophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperazin-1-yl)methanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1196691-73-2
(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 5856-62-2
(S)-2-aminobutan-1-ol

: 1196691-73-2
(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

: 7693-46-1
4-Nitrophenyl chloroformate

: 1196691-74-3
(S)-1-(4-(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)-benzyl)piperazine-1-carbonyl)-2-fluorophenyl)-3-(1-hydroxybutan-2-yl)urea

Guidance literature:: (4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone; 4-Nitrophenyl chloroformate; In dichloromethane; at 20 ℃; for 0.5h;

(S)-2-aminobutan-1-ol; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8
pyrimidin-4-amine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1196691-73-2
(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone

: 1196693-35-2
1-(4-(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)-benzyl)piperazine-1-carbonyl)-2-fluorophenyl)-3-(pyrimidin-4-yl)urea

Guidance literature:: pyrimidin-4-amine; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

(4-amino-3-fluorophenyl)(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoro-propan-2-yl)benzyl)piperazin-1-yl)methanone; In dichloromethane; at 120 ℃; for 0.166667h; microwave;