Technology Process of ((1S)-1-benzyl-3-cyclopropylamino-2-hydroxy-3-oxopropyl)carbamic acid 1,1-dimethylethyl ester
There total 12 articles about ((1S)-1-benzyl-3-cyclopropylamino-2-hydroxy-3-oxopropyl)carbamic acid 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
Cyclopropylamine;
With
benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/cmdc.202000385
- Guidance literature:
-
cyclopropyl isocyanide; Boc-L-phenylalaninal;
With
acetic acid;
In
dichloromethane;
at 20 ℃;
for 0.25h;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogen sulfite / methanol; H2O / 5 °C
1.2: H2O; methanol; ethyl acetate / 5 h / 20 °C
2.1: HCl / H2O; dioxane / Heating
3.1: 12 g / NaOH / dioxane; H2O / 18 h / 20 °C / pH 11
4.1: 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide; H2O / 20 °C
With
hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.04.059
