N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride

Base Information

• Chemical Name: N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride
• CAS No.: 911641-03-7
• Molecular Formula: C₁₈H₂₆N₄O₄S*ClH
• Molecular Weight: 430.956

Synonyms:N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride

Chemical Property of N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride

There total 4 articles about N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide (911641-02-6) → N1-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride (911641-03-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 96h;

Reference yield:

1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate (875551-47-6) → N1-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride (911641-03-7)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 43 h / 760.05 Torr

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane; ethyl acetate / 48 h

4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h

5: hydrogenchloride / 1,4-dioxane; methanol / 96 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;

Reference yield:

tert-butyl N-[[(2S)-morpholin-2-yl]methyl]carbamate (875551-59-0) → N1-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide hydrochloride (911641-03-7)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; ethyl acetate / 48 h

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h

4: hydrogenchloride / 1,4-dioxane; methanol / 96 h

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;

upstream raw materials:

N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

tert-butyl N-[[(2S)-morpholin-2-yl]methyl]carbamate

1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate

1,1-dimethylethyl ({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)carbamate

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