Technology Process of Carbamic acid, N-[[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl]-, 1,1-dimethyleth
There total 1 articles about Carbamic acid, N-[[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl]-, 1,1-dimethyleth which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Chiracel OD column;
In
ethanol; hexane;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogen / palladium 10% on activated carbon / methanol / 43 h / 760.05 Torr
2: triethylamine / dichloromethane / 16 h / 0 - 20 °C
3: hydrogenchloride / 1,4-dioxane; ethyl acetate / 48 h
4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h
5: hydrogenchloride / 1,4-dioxane; methanol / 96 h
6: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h
With
hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / methanol / 43 h / 760.05 Torr
2: triethylamine / dichloromethane / 16 h / 0 - 20 °C
With
hydrogen; triethylamine;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
