3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide

Base Information

Chemical Name:3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide
CAS No.:43196-25-4
Molecular Formula:C11H11Cl2NO2
Molecular Weight:260.12
Hs Code.:
Nikkaji Number:J75.204E
Wikidata:Q76326031
Mol file:43196-25-4.mol

Synonyms:3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide;43196-25-4;CINNAMAMIDE, 3,4-DICHLORO-N-(2-HYDROXYETHYL)-;2-Propenamide, 3-(3,4-dichlorophenyl)-N-(2-hydroxyethyl)-;AKOS008930246;LS-53916;N-(2-Hydroxyethyl)-3-(3,4-dichlorophenyl)propenamide

Suppliers and Price of 3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide

Chemical Property:

Vapor Pressure:3.32E-11mmHg at 25°C
Boiling Point:509.5°C at 760 mmHg
Flash Point:262°C
PSA：0.00000
Density:1.363g/cm³
LogP:0.00000
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:259.0166840
Heavy Atom Count:16
Complexity:258

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1C=CC(=O)NCCO)Cl)Cl
Isomeric SMILES:C1=CC(=C(C=C1/C=C/C(=O)NCCO)Cl)Cl

Technology Process of 3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide

There total 2 articles about 3,4-Dichloro-N-(2-hydroxyethyl)cinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39156-98-4,82476-03-7
(E)-3,4-dichlorocinnamoyl chloride

: 141-43-5
ethanolamine

: 43196-25-4
3-(3,4-dichloro-phenyl)-N-(2-hydroxy-ethyl)-acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2006.08.055

Reference yield:

: 7312-27-8
3,4-Dichlorocinnamic acid

: 43196-25-4
3-(3,4-dichloro-phenyl)-N-(2-hydroxy-ethyl)-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂ / 2 h / 20 °C

2: DIPEA / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.bmcl.2006.08.055