20-methoxy-20-oxooctadecanoic acid

Base Information

• Chemical Name: 20-methoxy-20-oxooctadecanoic acid
• CAS No.: 1767-98-2
• Molecular Formula: C₂₁H₄₀O₄
• Molecular Weight: 356.546
• Mol file: 1767-98-2.mol

Synonyms:20-methoxy-20-oxoicosanoic acid

Chemical Property of 20-methoxy-20-oxooctadecanoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 20-methoxy-20-oxooctadecanoic acid

There total 4 articles about 20-methoxy-20-oxooctadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,18-octadecanoic acid dimethyl ester (42235-38-1) → 20-methoxy-20-oxoicosanoic acid (1767-98-2)

Guidance literature:

With methanol; barium(II) hydroxide; at 50 ℃; for 48h;

Reference yield:

tert-butyl icosanedioic acid → eicosanedioic acid mono(1,1-dimethylethyl)ester (683239-16-9) + octadecane-1,18-dicarboxylic acid (2424-92-2) + 20-methoxy-20-oxoicosanoic acid (1767-98-2)

Guidance literature:

With methanol; barium hydroxide octahydrate; at 30 - 35 ℃; for 14.5h;

Reference yield:

10-bromodecanoic acid (50530-12-6) → eicosanedioic acid mono(1,1-dimethylethyl)ester (683239-16-9) + octadecane-1,18-dicarboxylic acid (2424-92-2) + 20-methoxy-20-oxoicosanoic acid (1767-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic anhydride / dichloromethane / 0.5 h / 0 °C / Large scale

1.2: 2 h / 0 - 10 °C / Large scale

2.1: zinc; nickel(II) chloride hexahydrate; 2,2':6,2''-terpyridine / N,N-dimethyl-formamide / 10 h / 35 - 45 °C / Inert atmosphere; Large scale

3.1: barium hydroxide octahydrate; methanol / 14.5 h / 30 - 35 °C

With methanol; 2,2':6,2''-terpyridine; nickel(II) chloride hexahydrate; barium hydroxide octahydrate; trifluoroacetic anhydride; zinc; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1,18-octadecanoic acid dimethyl ester

10-bromodecanoic acid

10-bromodecanoic acid tert-butyl ester

Downstream raw materials:

Nonadecan-1,19-disaeure-monomethylester

1,19-nonadecanedioic acid