(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

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Chemical Name:(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one
CAS No.:187949-57-1
Molecular Formula:C₂₀H₁₇F₃N₆O₂
Molecular Weight:430.389
Hs Code.:

Synonyms:(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

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Chemical Property of (1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

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Technology Process of (1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

There total 4 articles about (1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 3473-63-0
formamidine acetic acid

: 1027905-92-5
2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide

: 3-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-6,7-difluoro-3H-quinazolin-4-one

: 187949-57-1
(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 110 ℃; for 18h;
DOI:10.1021/jm9707277

Reference yield:

: 83506-93-8
2-amino-4,5-difluorobenzoic acid

: 187949-57-1
(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 43 percent / 5N aq. HCl / dioxane / 18 h / 110 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277

Reference yield:

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 187949-57-1
(1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 43 percent / 5N aq. HCl / dioxane / 18 h / 110 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277