2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

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Chemical Name:2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide
CAS No.:911312-97-5
Molecular Formula:C₂₁H₂₄ClN₃O₂
Molecular Weight:385.893
Hs Code.:

Synonyms:2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

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Chemical Property of 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

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Technology Process of 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

There total 2 articles about 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911312-95-3
2-chloro-N-(2-formylphenyl)-4-pyrrolidin-1-ylbenzamide

: 35320-23-1
(R)-2-aminopropan-1-ol

: 911312-97-5
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Guidance literature:: With potassium carbonate; In ethanol; for 1h; Heating / reflux;

Reference yield:

: 192513-60-3
2-chloro-(4-pyrrolidin-1-yl) benzoic acid

: 911312-97-5
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 66 h / 0 - 20 °C

3: potassium carbonate / ethanol / 1 h / Heating / reflux

With thionyl chloride; potassium carbonate; triethylamine; 1-methyl-pyrrolidin-2-one; In ethanol; dichloromethane;