192513-60-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-4-(1-pyrrolidinyl)benzenecarboxylic acid is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2-CHLORO-4-(1-PYRROLIDINYL)BENZENECARBOXYLIC ACID serves as a key component in the creation of pesticides and other crop protection agents, enhancing agricultural productivity and crop protection.
Used as an Antiparasitic Agent:
2-Chloro-4-(1-pyrrolidinyl)benzenecarboxylic acid has been studied for its potential as an antiparasitic agent, offering a possible treatment for various parasitic infections.
Used as an Antiviral Agent:
Research has also explored the compound's potential as an antiviral agent, suggesting its use in combating viral diseases and infections.
Used in Cancer Research:
2-Chloro-4-(1-pyrrolidinyl)benzenecarboxylic acid has been investigated for its ability to inhibit enzymes involved in cancer cell proliferation, indicating its potential use in cancer treatment and therapy development.
Overall, 2-CHLORO-4-(1-PYRROLIDINYL)BENZENECARBOXYLIC ACID's multifaceted applications highlight its significance in advancing various industries, particularly in the development of new therapeutic agents and protective measures.

Upstream product

• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 
• 175153-38-5 2-chloro-4-(pyrrolidin-1-yl)benzoic acid methyl ester 

Downstream Products

• 192513-61-4 methyl [1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl] acetate 
• 911312-97-5 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide 
• 911313-09-2 2-Chloro-N-(2-{[(R)-2-hydroxy-1-methylethyl(4-nitrobenzenesulfonyl)amino]methyl}phenyl)-4-pyrrolidin-1-ylbenzamide 
• 911313-12-7 (R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate 
• 911313-02-5 N-(2-{[(R)-2-(tert-butyldimethylsilanyloxy)-1-methylethylamino]methyl}phenyl)-2-chloro-4-pyrrolidin-1-ylbenzamide 
• 911313-03-6 tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate 
• 911313-15-0 tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate 
• 911312-98-6 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide 
• 911313-58-1 2-chloro-4-pyrrolidin-1-ylphenyl((R)-3-methyl-2,3,4,5-tetrahydrobenzo[e]-1,4-diazepin-1-yl)methanone 
• 192513-65-8 (1R)-1-methylhexyl (5R)-[1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetate 
• 192514-54-8 OPC 51803 
• 192514-55-9 (5R)-[1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetic acid 
• 192513-62-5 [1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl] acetic acid 

Relevant academic research and scientific papers

Mild, Metal-Free Oxidative Ring-Expansion Approach for the Synthesis of Benzo[ b]azepines

Benzo[b]azepines are important structural motifs for the pharmaceutical industry. However, their syntheses are usually lengthy, involving several steps, transition-metal catalysts, and/or harsh conditions. A novel, general, mild, and metal-free oxidative ring expansion tandem reaction of hydroquinolines with TMSCHN2 as a versatile soft nucleophile to gain access to these valuable compounds in a simple and straightforward manner is presented.

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.

4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF

4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.

Novel design of nonpeptide AVP V2 receptor agonists: Structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a template

The discovery of a series of nonpeptide arginine vasopressin V2 receptor agonists is described. After identifying the aniline derivative 8 as our lead compound from the metabolites of compound 7 that showed antidiuretic activity by po administr