2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Base Information

Chemical Name:2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide
CAS No.:911312-98-6
Molecular Formula:C₂₁H₂₆ClN₃O₂
Molecular Weight:387.909
Hs Code.:

Synonyms:2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

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Chemical Property of 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

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Technology Process of 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

There total 3 articles about 2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911312-97-5
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylimino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

: 911312-98-6
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Guidance literature:: With sodium tetrahydroborate; ethanol; at 20 ℃; Heating / reflux;

Reference yield:

: 192513-60-3
2-chloro-(4-pyrrolidin-1-yl) benzoic acid

: 911312-98-6
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 66 h / 0 - 20 °C

3: potassium carbonate / ethanol / 1 h / Heating / reflux

4: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; triethylamine; 1-methyl-pyrrolidin-2-one; In ethanol; dichloromethane;

Reference yield:

: 911312-93-1
2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

: 911312-98-6
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 66 h / 0 - 20 °C

2: potassium carbonate / ethanol / 1 h / Heating / reflux

3: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

With sodium tetrahydroborate; ethanol; potassium carbonate; triethylamine; In ethanol; dichloromethane;