(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Base Information

Chemical Name:(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)
CAS No.:132592-11-1
Molecular Formula:C₂₅H₂₉NO₆
Molecular Weight:439.508
Hs Code.:

Synonyms:(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Suppliers and Price of (2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

There total 4 articles about (2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3282-30-2
pivaloyl chloride

: 13500-53-3
N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester

: 132592-11-1
(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo00008a040

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 132592-11-1
(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / H₂O; dioxane / 10 °C

2: K₂CO₃, NaI / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; potassium carbonate; sodium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00008a040

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 132592-11-1
(2S,4R)-4-(pivaloyloxy)-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / H₂O; dioxane / 10 °C

2: K₂CO₃, NaI / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; potassium carbonate; sodium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00008a040