Technology Process of (2-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]-phenyl}-ethyl)-trimethyl-ammonium iodide
There total 21 articles about (2-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]-phenyl}-ethyl)-trimethyl-ammonium iodide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
acetonitrile;
at 50 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: Tris(trimethylsilyl) phosphate / tetrahydrofuran / 17 h / 75 °C / Inert atmosphere
2.1: urea hydrogen peroxide adduct / ethanol / 2 h / 20 °C
2.2: 2 h / 20 °C
3.1: triethylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere
4.1: ethanol / 1 h / 160 °C / Microwave irradiation
5.1: daicel chiralpak IC colunm (5 μm, 250 mmx10 mm)
6.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; copper(II) iodide / 1,4-dioxane / 1.25 h / 130 °C / Microwave irradiation; Inert atmosphere
7.1: silver nitrate; N-Bromosuccinimide / acetone / 2 h / Cooling with ice
8.1: tetrahydrofuran; acetonitrile / 18 h
9.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
10.1: acetonitrile / 1.5 h / 50 °C
With
methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; Tris(trimethylsilyl) phosphate; urea hydrogen peroxide adduct; silver nitrate; copper(II) iodide; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: Tris(trimethylsilyl) phosphate / tetrahydrofuran / 17 h / 75 °C / Inert atmosphere
2.1: urea hydrogen peroxide adduct / ethanol / 2 h / 20 °C
2.2: 2 h / 20 °C
3.1: triethylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere
4.1: ethanol / 1 h / 160 °C / Microwave irradiation
5.1: daicel chiralpak IC colunm (5 μm, 250 mmx10 mm)
6.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; copper(II) iodide / 1,4-dioxane / 1.25 h / 130 °C / Microwave irradiation; Inert atmosphere
7.1: silver nitrate; N-Bromosuccinimide / acetone / 2 h / Cooling with ice
8.1: tetrahydrofuran; acetonitrile / 18 h
9.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
10.1: acetonitrile / 1.5 h / 50 °C
With
methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; Tris(trimethylsilyl) phosphate; urea hydrogen peroxide adduct; silver nitrate; copper(II) iodide; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; acetonitrile;
![(R)-5-[4-cyano-2-(2-dimethylamino-ethyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
