(E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

• Chemical Name: (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS No.: 115984-23-1
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• Mol file: 115984-23-1.mol

Synonyms:(E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property of (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

• Melting Point: 204-206 °C
• Boiling Point: 413.2±48.0 °C(Predicted)
• PKA: -2.19±0.20(Predicted)
• Density: 1.324±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 5 articles about (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

(E)-3-phenylpropenal (14371-10-9) + 1,3-dimethylbarbituric acid (769-42-6) → (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (115984-23-1)

Guidance literature:

With hydrogenchloride; for 2h; Ambient temperature;

DOI:10.1021/ja973166h

Reference yield:

benzaldehyde (100-52-7) → (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (115984-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 80 °C

2: ethanol / 12 h / 20 °C

In ethanol; toluene;

DOI:10.1021/acs.orglett.0c02508

Reference yield:

1,3-dimethylbarbituric acid (769-42-6) + 3-phenyl-propenal (104-55-2) → 5-cinnamylidene-1,3-dimethyl-barbituric acid (110449-11-1,115984-23-1)

Guidance literature:

With water; 1.3-dimethyl-5-cinnamylidene-barbituric acid;

upstream raw materials:

1,3-dimethylbarbituric acid

3-phenyl-propenal

(E)-3-phenylpropenal

benzaldehyde

Downstream raw materials:

(1α,2α,3β,4β)-1,3-Bis(1,2,3,4,5,6-hexahydro-1,3-dimethyl-2,4,6-trioxo-5-pyrimidinylidenmethyl)-2,4-diphenylcyclobutan

1,3-dimethyl-5-(3-phenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione