benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate

Base Information

• Chemical Name: benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate
• CAS No.: 1102143-04-3
• Molecular Formula: C₃₁H₃₆N₂O₅
• Molecular Weight: 516.637
• Mol file: 1102143-04-3.mol

Synonyms:benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate

Chemical Property of benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate

There total 3 articles about benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(chloromethoxy)benzene (6707-01-3) + benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-4-phenylbutan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate (294885-34-0) → benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate (1102143-04-3)

Guidance literature:

(chloromethoxy)benzene; With magnesium; mercury dichloride; In tetrahydrofuran; Reflux; Inert atmosphere;

benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-4-phenylbutan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate; In tetrahydrofuran; at -78 - -25 ℃; for 0.75h; Inert atmosphere;

DOI:10.1021/jm1009567

Reference yield:

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid (1256776-43-8) → benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate (1102143-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: magnesium; mercury dichloride / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 0.75 h / -78 - -25 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; mercury dichloride; In tetrahydrofuran; dichloromethane; 2.2: Grignard reaction;

DOI:10.1021/jm1009567

Reference yield:

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid methyl ester (1256776-36-9) → benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate (1102143-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol / 20 °C

2.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: magnesium; mercury dichloride / tetrahydrofuran / Reflux; Inert atmosphere

3.2: 0.75 h / -78 - -25 °C / Inert atmosphere

With dmap; water; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; mercury dichloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 3.2: Grignard reaction;

DOI:10.1021/jm1009567

upstream raw materials:

(chloromethoxy)benzene

benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-4-phenylbutan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid methyl ester

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid