2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid

Base Information

• Chemical Name: 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid
• CAS No.: 1256776-43-8
• Molecular Formula: C₂₄H₃₀N₂O₅
• Molecular Weight: 426.513
• Mol file: 1256776-43-8.mol

Synonyms:2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid

Chemical Property of 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid

There total 1 articles about 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid methyl ester (1256776-36-9) → 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid (1256776-43-8)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1021/jm1009567

Reference yield: 66.0%

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid (1256776-43-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-4-phenylbutan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate (294885-34-0)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm1009567

Reference yield:

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid (1256776-43-8) → C36H48N2O7 (1256776-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: magnesium; mercury dichloride / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 0.75 h / -78 - -25 °C / Inert atmosphere

3.1: ozone / dichloromethane; pentane / -78 - 0 °C

With dmap; benzotriazol-1-ol; ozone; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; mercury dichloride; In tetrahydrofuran; dichloromethane; pentane; 2.2: Grignard reaction / 3.1: Griesbaum co-ozonolysis;

DOI:10.1021/jm1009567

upstream raw materials:

2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid methyl ester

Downstream raw materials:

benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-4-phenylbutan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate

C₃₆H₄₈N₂O₇

C₃₇H₅₀N₂O₇

benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate