hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Base Information

Chemical Name:hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester
CAS No.:1377567-59-3
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Suppliers and Price of hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

There total 4 articles about hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377567-57-1
3-amino-(5,6,7,8-tetrahydro-naphthalen-2-yl)-p-tolyl-methanone

: 615-79-2
ethyl 2,4-diketopentanoate

: 1377567-59-3
hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Guidance literature:: 3-amino-(5,6,7,8-tetrahydro-naphthalen-2-yl)-p-tolyl-methanone; ethyl 2,4-diketopentanoate; With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In ethanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 104877-13-6
3-amino-5,6,7,8-tetrahydro-napthalene-2-carboxylic acid

: 1377567-59-3
hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.1: dichloromethane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: -42 - 20 °C / Saturated solution

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / Inert atmosphere; Reflux

4.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With chloro-trimethyl-silane; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1377567-55-9
2-phenyl-6,7,8,9-tetrahydro-naphtho[2,3-d][1,3]oxazin-4-one

: 1377567-59-3
hydroxy-(2-methyl-4-p-tolyl-6,7,8,9-tetrahydro-benzo[g]quinolin-3-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -42 - 20 °C / Saturated solution

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / Inert atmosphere; Reflux

3.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With chloro-trimethyl-silane; water; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;