218771-68-7

Basic information

• Product Name: Ethanone,1-(2-fluorophenyl)-2-hydroxy-(9CI)
• Synonyms: Ethanone,1-(2-fluorophenyl)-2-hydroxy-(9CI);Ethanone, 1-(2-fluorophenyl)-2-hydroxy-
• CAS NO: 218771-68-7
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• Product Categories: HALIDE
• Mol File: 218771-68-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone,1-(2-fluorophenyl)-2-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-fluorophenyl)-2-hydroxy-(9CI)(218771-68-7)
• EPA Substance Registry System: Ethanone,1-(2-fluorophenyl)-2-hydroxy-(9CI)(218771-68-7)

Safety Data

• Hazardous Substances Data: 218771-68-7(Hazardous Substances Data)

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 298-12-4 Glyoxilic acid 
• 67-56-1 methanol 
• 179242-97-8 ((1-(2-fluorophenyl)vinyl)oxy)trimethylsilane 
• 67-64-1 acetone 
• 445-27-2 2'-Fluoroacetophenone 
• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 711-90-0 α-acetoxy-2-fluoroacetophenone 
• 348-52-7 1-Fluoro-2-iodobenzene 

Downstream Products

• 1402412-84-3 2-fluoro-1-(2-fluorophenyl)ethan-1-one 
• 1415914-97-4 (R)-2-methyl-propane-2-sulfinic acid [2-fluoro-1-(2-fluoro-phenyl)-eth-(E)-ylidene]-amide 
• 1402412-91-2 (2S,3S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,4-difluoro-3-(2-fluorophenyl)butanoate 
• 1415914-98-5 (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate 
• 1402413-06-2 (2R,3S)-3-amino-2,4-difluoro-3-(2-fluorophenyl)butan-1-ol 
• 1415915-00-2 (S)-3-amino-2,2,4-trifluoro-3-(2-fluoro-phenyl)-butan-1-ol 
• 1402413-14-2 (4R,5R)-5-fluoro-4-(fluoromethyl)-4-(2-fluorophenyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1415915-01-3 (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1402413-24-4 (4R,5R)-5-fluoro-4-(2-fluoro-5-nitrophenyl)-4-(fluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1415915-02-4 (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1402413-31-3 (4R,5S)-4-(5-amino-2-fluorophenyl)-5-fluoro-4-(fluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1415915-03-5 (S)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1415914-91-8 (S)-N-(3-(2-amino-5,5-difluoro-4-(fluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 

Relevant articles and documents

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

An Ir/Zn dual catalysis has been developed for the enantio- and diastereodivergent α-allylation of unprotected α-hydroxyketones under mild conditions, in the absence of any additional base. The cooperative action of a chiral iridium complex derived from phosphoramidites and a chiral Zn-ProPhenol complex is most likely responsible for its high reactivity, excellent enantioselectivity (up to >99% ee), and good diastereoselectivity (up to >20:1 dr). All four product stereoisomers could be prepared from the same set of starting materials and under identical conditions by simple selection of appropriate catalyst combinations.

Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties

An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).

Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes

A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.