C₂₀H₂₁N₃O₃

Base Information

• Chemical Name: C₂₀H₂₁N₃O₃
• CAS No.: 1246520-95-5
• Molecular Formula: C₂₀H₂₁N₃O₃
• Molecular Weight: 351.405
• Mol file: 1246520-95-5.mol

Synonyms:C₂₀H₂₁N₃O₃

Chemical Property of C₂₀H₂₁N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁N₃O₃

There total 5 articles about C₂₀H₂₁N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H15N3O3 (1137734-93-0) + ethyllithium (811-49-4) → C20H21N3O3 (1246520-95-5)

Guidance literature:

C₁₈H₁₅N₃O₃; ethyllithium; copper(l) iodide; In tetrahydrofuran; diethyl ether; cyclohexane; benzene; at -78 ℃; for 0.833333h;

With water; In tetrahydrofuran; diethyl ether; cyclohexane; benzene; at -78 ℃;

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → C20H21N3O3 (1246520-95-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: sodium hydrogencarbonate / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

5.1: copper(l) iodide / cyclohexane; benzene; diethyl ether; tetrahydrofuran / 0.83 h / -78 °C

5.2: -78 °C

With iodine; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; hydrazine hydrate; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide; benzene;

Reference yield:

3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → C20H21N3O3 (1246520-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: sodium hydrogencarbonate / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

3.1: copper(l) iodide / cyclohexane; benzene; diethyl ether; tetrahydrofuran / 0.83 h / -78 °C

3.2: -78 °C

With sodium hydride; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide; benzene;

upstream raw materials:

C₁₈H₁₅N₃O₃

ethyllithium

2-chloro-3-carbaldehydepyridine

3-iodo-1H-pyrazolo[3,4-b]pyridine

Downstream raw materials:

C₂₂H₂₇N₅O₃