4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

Base Information

Chemical Name:4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide
CAS No.:261787-69-3
Molecular Formula:C₃₀H₂₃BrN₂O₃
Molecular Weight:539.428
Hs Code.:

Synonyms:4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

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Chemical Property of 4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

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Technology Process of 4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

There total 4 articles about 4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 168626-54-8
N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide

: 261787-69-3
4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

Guidance literature:: With hydrogen bromide; bromine; acetic acid; at 20 ℃; for 1h;
DOI:10.1248/cpb.48.21

Reference yield:

: 947-84-2
2-Biphenylcarboxylic acid

: 261787-69-3
4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / -15 - 25 °C

2: triethylamine / dichloromethane

3: copper(ll) bromide / chloroform; ethyl acetate

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; copper(ll) bromide; In dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/op034079e

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 261787-69-3
4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: copper(ll) bromide / chloroform; ethyl acetate

With triethylamine; copper(ll) bromide; In dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/op034079e