4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide

Base Information

• Chemical Name: 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide
• CAS No.: 168626-66-2
• Molecular Formula: C₄₁H₃₁N₅O₄
• Molecular Weight: 657.728
• Mol file: 168626-66-2.mol

Synonyms:4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide

Chemical Property of 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide

There total 3 articles about 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phthalimidopropionamidine (41648-83-3) + copper(II)bromide (7789-45-9) + N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide (168626-54-8) → 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide (168626-66-2)

Guidance literature:

With sodium hydrogencarbonate; potassium carbonate; In chloroform; ethyl acetate;

Reference yield:

N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide (168626-54-8) → 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide (168626-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Br₂; HBr; AcOH / 1 h / 20 °C

2: K₂CO₃ / CHCl₃ / 18 h / Heating

With hydrogen bromide; bromine; potassium carbonate; acetic acid; In chloroform; 1: Bromination / 2: cyclocondensation;

DOI:10.1248/cpb.48.21

Reference yield:

(phthalimido-2-yl)propionamidine hydrochloride + 4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide (261787-69-3) → 4'-[2-(phthalimido-2-yl)ethyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl]-2-phenylbenzanilide (168626-66-2)

Guidance literature:

With potassium carbonate; In chloroform; for 18h; Heating;

DOI:10.1248/cpb.48.21

upstream raw materials:

4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide

N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide

3-phthalimidopropionamidine

copper(II)bromide