2-chloro-N-(3,4-dimethylphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(3,4-dimethylphenyl)acetamide
• CAS No.: 2564-04-7
• Molecular Formula: C10H12 Cl N O
• Molecular Weight: 197.664
• Hs Code.: 2924299090
• Mol file: 2564-04-7.mol

Synonyms:3',4'-Acetoxylidide,2-chloro- (7CI,8CI); 2-Chloro-N-(3,4-dimethylphenyl)acetamide; NSC 17833

Chemical Property of 2-chloro-N-(3,4-dimethylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 5.21E-05mmHg at 25°C
• Melting Point: 55 °C
• Boiling Point: 347.9°Cat760mmHg
• PKA: 12.90±0.70(Predicted)
• Flash Point: 164.2°C
• PSA: 29.10000
• Density: 1.187g/cm³
• LogP: 2.55370

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(3,4-dimethylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-N-(3,4-dimethylphenyl)acetamide

There total 6 articles about 2-chloro-N-(3,4-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.82%

4-amino-o-xylene (95-64-7) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(3,4-dimethylphenyl)acetamide (2564-04-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.08.041

Reference yield: 73.0%

4-amino-o-xylene (95-64-7) + Chloroacetamide (79-07-2) → 2-chloro-N-(3,4-dimethylphenyl)acetamide (2564-04-7)

Guidance literature:

With pyridine; In benzene; at 20 - 60 ℃; for 5h;

DOI:10.1134/S1070428021020093

Reference yield:

4-amino-o-xylene (95-64-7) → 2-chloro-N-(3,4-dimethylphenyl)acetamide (2564-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride / 10 h / Reflux

2: 1,2-dichloro-ethane / 0 - 20 °C

With ammonium chloride; In 1,2-dichloro-ethane;

DOI:10.1016/j.tetlet.2012.11.090

upstream raw materials:

4-amino-o-xylene

chloroacetic acid

chloroacetyl chloride

Chloroacetamide

Downstream raw materials:

pyrrolidino-acetic acid-(3,4-dimethyl-anilide)

piperidino-acetic acid-(3,4-dimethyl-anilide)

morpholino-acetic acid-(3,4-dimethyl-anilide)

1-[(3,4-dimethyl-phenylcarbamoyl)-methyl]-pyridinium; chloride

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