Technology Process of ethyl 4-(4-(1-azidoethyl)-2-methoxy-5-nitrophenoxy)butanoate
There total 6 articles about ethyl 4-(4-(1-azidoethyl)-2-methoxy-5-nitrophenoxy)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 12h;
DOI:10.1039/c0cc05274d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 50 °C
2: nitric acid / acetic anhydride / 3 h / 0 °C
3: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C
4: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C
5: sodium azide / N,N-dimethyl-formamide / 12 h / 60 °C
With
sodium tetrahydroborate; thionyl chloride; sodium azide; nitric acid; potassium carbonate;
In
methanol; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05274d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 50 °C
2: nitric acid / acetic anhydride / 3 h / 0 °C
3: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C
4: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C
5: sodium azide / N,N-dimethyl-formamide / 12 h / 60 °C
With
sodium tetrahydroborate; thionyl chloride; sodium azide; nitric acid; potassium carbonate;
In
methanol; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05274d
